What description best defines the oral gavage procedure?

• A. The administration of fluid into the bloodstream through an injection.
• B. The administration of fluid into the stomach through a feeding needle that is inserted into the mouth and threaded down the esophagus.
• C. Administration into the peritoneal cavity.
• D. Inhalation of anesthetic gas.

Answer: (B)

Oral gavage is the technique of delivering a precise volume of liquid directly to the stomach by threading a gavage needle through the mouth and down the esophagus. This method is used to ensure the substance reaches the stomach for accurate dosing in mice and other small animals, rather than relying on absorption from the oral cavity or alternative routes. A gavage needle or soft feeding tube is used, and proper restraint and technique are essential to guide the tip to the stomach and avoid injury or misplacement that could lead to aspiration. The volume is typically calculated based on body weight and the protocol being followed. The other options describe different administration routes or purposes: delivering fluid into the bloodstream, into the peritoneal cavity, or inhaling anesthetic gas.