Who is responsible for humane treatment of experimental animals?

• A. The principal investigator.
• B. The Animal Care staff.
• C. The IACUC.
• D. All of the Above.

Answer: (D)

Humane treatment of experimental animals is ensured through shared responsibility across roles. The principal investigator designs the study with attention to minimizing pain and distress, establishing humane endpoints, and making sure the protocol is followed so animal welfare is protected. The animal care staff handle daily husbandry, monitoring of health and well-being, proper housing and enrichment, and prompt veterinary notification and care when issues arise. The IACUC provides independent oversight, reviews and approves protocols, conducts facility and program reviews, and enforces compliance with laws and guidelines to safeguard welfare. Because welfare is maintained through this combination of thoughtful study design, attentive daily care, and rigorous oversight, all three groups share the responsibility. Therefore, all of the above are responsible for humane treatment.